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Regulation of blood flow in diabetic retinopathy
Visual Neuroscience ( IF 1.9 ) Pub Date : 2020-07-20 , DOI: 10.1017/s0952523820000036
Amy R Nippert 1 , Eric A Newman 1
Affiliation  

Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands vary. This response, termed “functional hyperemia,” is disrupted in diabetic retinopathy. The reduction in functional hyperemia may result in retinal hypoxia and contribute to the development of retinopathy. This review will discuss the neurovascular coupling signaling mechanisms that generate the functional hyperemia response in the retina, the changes to neurovascular coupling that occur in diabetic retinopathy, possible treatments for restoring functional hyperemia and retinal oxygen levels, and changes to functional hyperemia that occur in the diabetic brain.

中文翻译:

糖尿病视网膜病变血流的调节

视网膜中的血流量会随着光诱发的神经元活动而增加,从而确保视网膜神经元随着代谢需求的变化而获得充足的氧气和营养供应。这种被称为“功能性充血”的反应在糖尿病视网膜病变中被破坏。功能性充血的减少可能导致视网膜缺氧并导致视网膜病变的发展。本综述将讨论在视网膜中产生功能性充血反应的神经血管耦合信号传导机制、糖尿病性视网膜病变中发生的神经血管耦合变化、恢复功能性充血和视网膜氧水平的可能治疗方法,以及在视网膜中发生的功能性充血的变化。糖尿病大脑。
更新日期:2020-07-20
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