Abstract

The presented work comprehensively discusses omeprazole (OMZ) and its S-active isomer (esomeprazole, ESZ) different methods of analysis indexed in Web of science, Scopus and Pub-med from 2016 till now. Chromatographic methods with different detectors each to fulfill the aim of the analysis were discussed. These chromatographic methods aimed to analyze OMZ and ESZ in biological fluids in presence of other drugs and metabolites for studying drug kinetics or drug-drug interaction and enzyme polymorphism. Moreover, in-vitro chromatographic methods were discussed for analyzing OMZ and ESZ in pharmaceuticals alone or in presence of other drugs. In addition, different chiral chromatographic methods separating the two enantiomers of OMZ (R-OMZ and ESZ) alone or with other chiral drugs or chiral impurities have been thoroughly discussed where no previous reviews have dealt with the chiral separation methods for OMZ and ESZ. Also, environmental analysis of OMZ and ESZ in various environmental samples was found as they are from the most popular drugs used and there is a high incidence that they may be present in wastewater. Moreover, reported spectroscopic and electrochemical methods for OMZ and ESZ analysis were discussed showing the structural features of OMZ/ESZ that lead to their successful analysis using spectroscopy and electrochemistry. Finally, the important figures of merit of all the discussed articles are shown in comprehensive tables and the article comprises 4 sections (chromatographic, electrochemical, spectroscopic and miscellaneous methods) and 7 tables.

摘要

所介绍的工作全面讨论了从 2016 年至今在 Web of science、Scopus 和 Pub-med 中索引的奥美拉唑 (OMZ) 及其 S 活性异构体 (esomeprazole, ESZ) 不同的分析方法。讨论了使用不同检测器实现分析目的的色谱方法。这些色谱方法旨在分析存在其他药物和代谢物的生物体液中的 OMZ 和 ESZ，以研究药物动力学或药物-药物相互作用和酶多态性。此外，还讨论了用于单独分析药物中的 OMZ 和 ESZ 或存在其他药物时的体外色谱方法。此外，单独或与其他手性药物或手性杂质分离 OMZ 的两种对映异构体（R-OMZ 和 ESZ）的不同手性色谱方法已被彻底讨论，以前没有评论涉及 OMZ 和 ESZ 的手性分离方法。此外，还发现了各种环境样品中的 OMZ 和 ESZ 的环境分析，因为它们来自最常用的药物，并且它们很可能存在于废水中。此外，讨论了报告的 OMZ 和 ESZ 分析的光谱和电化学方法，显示了 OMZ/ESZ 的结构特征，这些特征导致它们使用光谱和电化学成功分析。最后，所有讨论文章的重要品质因数都显示在综合表格中，文章包括 4 个部分（色谱、