Objective: The aim of the study was to determine the risk of multiple sclerosis (MS) conversion after optic neuritis (ON) and to identify the predictive factors on conversion in Turkish patients. Methods: Patients whose first clinical attacks had been ON were included in the study. The primary end point was the diagnosis of clinical relapse-remitting MS. Result: Except for the bilateral involvement rate, the clinical and demographic characteristics of the cohort are similar to Western studies. Though one-third of the patients with ON had bilateral involvement, bilateral involvement reduces the risk of conversion. Also, active lesions at the initial cranial magnetic resonance imagination increase the conversion rate. Conclusion: This research confirms previous findings and contributes additional evidence that if the patients have unilateral involvement and active lesions, they should be closely monitored. Moreover, our research supports the hypothesis that risk factors may be affected by racial, environmental, and genetic factors.

中文翻译：

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视神经炎转化为复发缓解型多发性硬化症：一项回顾性合并症队列研究

目的：本研究的目的是确定视神经炎 (ON) 后多发性硬化 (MS) 转换的风险，并确定土耳其患者转换的预测因素。方法：研究中包括首次临床发作为 ON 的患者。主要终点是临床复发缓解型 MS 的诊断。结果：除双侧受累率外，该队列的临床和人口统计学特征与西方研究相似。虽然三分之一的 ON 患者双侧受累，但双侧受累降低了转换风险。此外，最初颅脑磁共振想象中的活动性病变增加了转化率。结论：这项研究证实了先前的发现，并提供了额外的证据，即如果患者有单侧受累和活动性病变，则应密切监测。此外，我们的研究支持风险因素可能受种族、环境和遗传因素影响的假设。