Since the end of 2019, the whole world has been struggling with the pandemic of the new Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). Available evidence suggests that pain is a common symptom during Coronavirus Disease 2019 (COVID-19). According to the World Health Organization, many patients suffer from muscle pain (myalgia) and/or joint pain (arthralgia), sore throat and headache. The exact mechanisms of headache and myalgia during viral infection are still unknown. Moreover, many patients with respiratory failure get admitted to the intensive care unit (ICU) for ventilatory support. Pain in ICU patients can be associated with viral disease itself (myalgia, arthralgia, peripheral neuropathies), may be caused by continuous pain and discomfort associated with ICU treatment, intermittent procedural pain and chronic pain present before admission to the ICU. Undertreatment of pain, especially when sedation and neuromuscular blocking agents are used, prone positioning during mechanical ventilation or extracorporeal membrane oxygenation (ECMO) may trigger delirium and cause peripheral neuropathies. This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. A structured prospective evaluation should be undertaken to analyze the probability, severity, sources and adequate treatment of pain in patients with COVID-19 infection.

中文翻译：

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COVID-19：SARS-CoV-2感染患者的疼痛管理-分子机制，挑战和观点。

自2019年底以来，全世界一直在与新型严重急性呼吸系统综合症冠状病毒（SARS-CoV-2）的大流行作斗争。现有证据表明，疼痛是2019年冠状病毒病（COVID-19）期间的常见症状。根据世界卫生组织，许多患者患有肌肉痛（肌痛）和/或关节痛（关节痛），喉咙痛和头痛。病毒感染期间头痛和肌痛的确切机制仍不清楚。此外，许多呼吸衰竭患者被送入重症监护病房（ICU）进行呼吸支持。ICU患者的疼痛可能与病毒性疾病本身（肌痛，关节痛，周围神经病）有关，可能是由于与ICU治疗相关的持续疼痛和不适引起的，入加护病房前存在间歇性程序性疼痛和慢性疼痛。疼痛的治疗不足，尤其是在使用镇静剂和神经肌肉阻滞剂时，在机械通气或体外膜氧合（ECMO）期间俯卧可能会触发del妄并引起周围神经病。该叙述性综述总结了有关COVID-19患者疼痛评估和治疗相关挑战的最新知识。应该进行结构化的前瞻性评估，以分析COVID-19感染患者疼痛的可能性，严重程度，来源和适当的治疗方法。机械通气或体外膜氧合（ECMO）期间俯卧可能会触发ir妄并引起周围神经病。该叙述性综述总结了有关COVID-19患者疼痛评估和治疗相关挑战的最新知识。应该进行结构化的前瞻性评估，以分析COVID-19感染患者疼痛的可能性，严重程度，来源和适当的治疗方法。机械通气或体外膜氧合（ECMO）期间俯卧可能会触发ir妄并引起周围神经病。该叙述性综述总结了有关COVID-19患者疼痛评估和治疗相关挑战的最新知识。应进行结构化的前瞻性评估，以分析COVID-19感染患者疼痛的可能性，严重程度，来源和适当的治疗方法。