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LncRNA GATA3‐AS1 facilitates tumour progression and immune escape in triple‐negative breast cancer through destabilization of GATA3 but stabilization of PD‐L1
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-07-20 , DOI: 10.1111/cpr.12855
Ming Zhang 1 , Ning Wang 2 , Peng Song 3 , Yingqiang Fu 1 , Yanlv Ren 1 , Zhigao Li 1 , Jinsong Wang 1
Affiliation  

Long non‐coding RNAs (lncRNAs) have been demonstrated as crucial regulators in cancer, but whether they are involved in the immune response of cancer cells remains largely undiscovered. GATA3‐AS1 is a novel lncRNA that was upregulated in breast cancer (BC) according to online databases. However, its role in triple‐negative breast cancer (TNBC) was elusive.

中文翻译:

LncRNA GATA3-AS1通过破坏GATA3但稳定PD-L1促进三阴性乳腺癌的肿瘤进展和免疫逃逸

长链非编码 RNA (lncRNAs) 已被证明是癌症的关键调节因子,但它们是否参与癌细胞的免疫反应在很大程度上仍未被发现。根据在线数据库,GATA3-AS1 是一种新型 lncRNA,在乳腺癌 (BC) 中上调。然而,它在三阴性乳腺癌(TNBC)中的作用是难以捉摸的。
更新日期:2020-07-20
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