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Polyelectrolyte Translocation through a Corrugated Nanopore
Macromolecular Theory and Simulations ( IF 1.4 ) Pub Date : 2020-07-19 , DOI: 10.1002/mats.202000042
Karthik Nagarajan 1 , Shing Bor Chen 1
Affiliation  

The problem of slowing down the rate of DNA translocation through a nanopore so as to facilitate detection of the genetic information remains a major challenge. In this study, the effectiveness of employing corrugated nanopores to reduce the polymer translocation velocity is investigated using dissipative particle dynamics (DPD) simulations. The average translocation time, <τ>, increases with the pore length and extent of variation of the pore cross‐sectional area. A systematic comparison of <τ> between flat and corrugated nanopores with walls that are either neutral or attractive for the polymer is performed. The value of <τ> for a corrugated nanopore with an attractive wall is 158% greater than that for a flat pore with a neutral wall. The extent of increase in <τ> obtained by manipulating either the geometry of the pore or the nature of its interaction with the polymer alone is significantly smaller. This is because the combined effect of monomer‐pore interactions and the spatial variation of the electric field strength significantly slows down the entry and escape of the chain from the pore.

中文翻译:

通过波纹纳米孔的聚电解质易位

减慢通过纳米孔的DNA易位速率以促进遗传信息的检测的问题仍然是主要挑战。在这项研究中,使用耗散粒子动力学(DPD)模拟研究了采用波纹纳米孔降低聚合物易位速度的有效性。平均移位时间<τ>随孔长和孔截面积变化程度的增加而增加。系统地比较了平坦的和波纹状的纳米孔与壁的中性或有吸引力的壁之间的<τ>。具有吸引壁的波纹状纳米孔的<τ>值比具有中性壁的扁平孔的值大158%。<τ>的增加程度 通过操纵孔的几何形状或其与聚合物本身的相互作用的性质而获得的产物明显较小。这是因为单体与孔之间的相互作用以及电场强度的空间变化的综合作用显着减慢了链从孔中的进入和逸出。
更新日期:2020-09-14
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