The use of nanoscale metal–organic frameworks (MOFs) as drug delivery vehicles has attracted considerable attention in tumor therapy. In this study, novel biocompatible MOF-based nanocarriers were used as part of a facile and reproducible strategy for precision cancer theranostics. Both diagnostic (Mn²⁺) and therapeutic compounds (doxorubicin, DOX) were incorporated into the multifunctional MOF-based nanocarriers, which exhibited high colloidal stability and promoted T₁-weighted proton relaxivity and low-pH-activated drug release. The obtained MOF-based nanocarriers exhibited significantly high cellular uptake and efficient intracellular drug delivery into cancer cells, which resulted in high apoptosis and cytotoxicity, in addition to effectively inhibiting the migration of 4T1 breast cancer cells. Moreover, the MOF-based nanocarriers could intensively deliver diagnostic and therapeutic agents to tumors to enable precise visualization of the nanocarrier accumulation and accurate tumor positioning, diagnosis, and imaging-guided therapy using magnetic resonance imaging (MRI). In addition, the functional MOF-based nanocarriers exhibited effective ablation of the primary breast cancer, as well as significant inhibition of lung metastasis with a high survival rate. Therefore, the developed nanocarriers represent a viable platform for cancer theranostics.

纳米级金属-有机骨架（MOF）作为药物传递工具的使用在肿瘤治疗中引起了相当大的关注。在这项研究中，新型的基于生物相容性MOF的纳米载体被用作精确的癌症治疗学方法的简便且可重现的策略的一部分。诊断性化合物（Mn ²⁺）和治疗性化合物（阿霉素，DOX）均被引入基于MOF的多功能纳米载体中，该载体表现出高的胶体稳定性并促进T ₁重质子弛豫和低pH活化药物释放。所获得的基于MOF的纳米载体显示出显着高的细胞摄取和有效的细胞内药物递送到癌细胞中，除了有效抑制4T1乳腺癌细胞的迁移外，还导致高的细胞凋亡和细胞毒性。此外，基于MOF的纳米载体可以向肿瘤密集地输送诊断和治疗剂，以实现纳米载体积聚的精确可视化以及使用磁共振成像（MRI）的精确肿瘤定位，诊断和成像引导疗法。此外，基于功能MOF的纳米载体表现出对原发性乳腺癌的有效消融，并以高存活率显着抑制了肺转移。因此，