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Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.
Fungal Genetics and Biology ( IF 3 ) Pub Date : 2020-07-20 , DOI: 10.1016/j.fgb.2020.103435
Cameron L M Gilchrist 1 , Heather J Lacey 2 , Daniel Vuong 2 , John I Pitt 2 , Lene Lange 3 , Ernest Lacey 4 , Bo Pilgaard 5 , Yit-Heng Chooi 1 , Andrew M Piggott 6
Affiliation  

Aspergillus burnettii is a new species belonging to the A. alliaceus clade in Aspergillus subgenus Circumdati section Flavi isolated from peanut-growing properties in southern Queensland, Australia. A. burnettii is a fast-growing, floccose fungus with distinctive brown conidia and is a talented producer of biomass-degrading enzymes and secondary metabolites. Chemical profiling of A. burnettii revealed the metabolites ochratoxin A, kotanins, isokotanins, asperlicin E, anominine and paspalinine, which are common to subgenus Circumdati, together with burnettiene A, burnettramic acids, burnettides, and high levels of 14α-hydroxypaspalinine and hirsutide. The genome of A. burnettii was sequenced and an annotated draft genome is presented. A. burnettii is rich in secondary metabolite biosynthetic gene clusters, containing 51 polyketide synthases, 28 non-ribosomal peptide synthetases and 19 genes related to terpene biosynthesis. Functional annotation of digestive enzymes of A. burnettii and A. alliaceus revealed overlapping carbon utilisation profiles, consistent with a close phylogenetic relationship.



中文翻译:

具有生物合成能力的澳大利亚真菌 Aspergillus burnettii sp. 的综合化学分类学和基因组分析。十一月

黑burnettii是属于一个新的物种A. alliaceus进化枝亚属Circumdati部分黄热病花生生长特性在昆士兰州南部,澳大利亚隔离。A.burnettii是一种快速生长的絮状真菌,具有独特的棕色分生孢子,是生物质降解酶和次生代谢物的天才生产者。A.burnettii 的化学分析揭示了 Circumdati 亚属常见的代谢物赭曲霉毒素 A、kotanins、isokotanins、asperlicin E、anominine 和paspalinine,连同burnettiene A、burnnettramic酸、burnettides和高水平的14α-羟基paspalinine和hirsutide。对A.burnettii的基因组进行了测序,并提供了带注释的基因组草图。A.burnettii富含次级代谢物生物合成基因簇,含有51个聚酮合酶、28个非核糖体肽合成酶和19个与萜烯生物合成相关的基因。A.burnettiiA. alliaceus消化酶的功能注释揭示了重叠的碳利用谱,与密切的系统发育关系一致。

更新日期:2020-07-29
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