Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27 hypomethylation, mirroring transcriptional and metabolic signatures of gliogenic progenitors involved in embryonal hindbrain development.

中文翻译：

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进入稀薄空气：低氧驱动致死性小儿室管膜瘤的代谢和表观基因调控。

后颅窝A型（PFA）室管膜瘤是一种致命的小儿脑肿瘤，提出仅由表观遗传失调驱动。Michealraj等。（2020）证明低氧会重编程PFA代谢，进而重编程H3K27甲基化的表观基因组，反映参与胚胎后脑发育的胶质祖细胞的转录和代谢特征。