Abstract

Commercially available p-aminobenzoic acid was used as a precursor for the synthesis of novel fused, non-fused, and spiro polyheterocyclic derivatives bearing indene, imidazole, pyrazole, and/or triazine nucleus via addition to simple and accessible reagents such as ninhydrin, o-phenylenediamine, and carbon disulfide. The experimental procedures were straightforward and simple, the products were isolated in 15–86% yields, and. their structure was confirmed by spectroscopic data. The synthesized compounds were evaluated for their antibacterial activity against some Gram-positive and Gram-negative bacteria.

中文翻译：

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芳香族氨基酸的杂环化：融合，非融合和螺多杂环衍生物的新型合成和抗菌活性。

摘要

可商购的p氨基苯甲酸被用作新颖的稠合的合成的前体，非稠合，螺环和多杂环衍生物轴承茚，咪唑，吡唑，和/或经由除了简单和方便的试剂如茚三酮，三嗪核ö -苯二胺和二硫化碳。实验步骤简单明了，分离出的产品收率为15–86％，并且。通过光谱数据证实了它们的结构。评价合成的化合物对某些革兰氏阳性和革兰氏阴性细菌的抗菌活性。