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Kinetic model of development of acute viral infection in the human body. Critical conditions, control mechanisms, “thermoheliox”
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2020-06-01 , DOI: 10.1007/s11172-020-2886-4
S D Varfolomeev 1, 2 , A A Panin 3 , V I Bykov 2 , S B Tsybenova 2 , L V Shogenova 4 , A G Chuchalin 4
Affiliation  

A kinetic model of the development of acute viral infection is proposed and the dynamic behavior of key variables, including the concentrations of viral particles, infected cells, and pathogenic microorganisms, is described. The change in the hydrogen ion concentration in the lungs and pH dependence of the activity of carbonic anhydrase, a key respiration enzyme, are critical factors. An acute bifurcation transition determining either the life or collapse of the system is demonstrated. The transition is associated with exponential increase in the concentrations of participants in the process and with functioning of the key enzyme, carbonic anhydrase. A physicochemical interpretation is given for the therapeutic effect of temperature rise and potential therapeutic effect of “thermoheliox”, that is, breathing by heated helium-oxygen mixture.

中文翻译:

人体内急性病毒感染发展的动力学模型。临界条件、控制机制、“thermoheliox”

提出了急性病毒感染发展的动力学模型,并描述了关键变量的动态行为,包括病毒颗粒、感染细胞和病原微生物的浓度。肺中氢离子浓度的变化和碳酸酐酶(一种关键的呼吸酶)活性的 pH 依赖性是关键因素。演示了决定系统寿命或崩溃的急性分叉转变。这种转变与该过程中参与者浓度的指数增加以及关键酶碳酸酐酶的功能有关。对温升的治疗作用和“thermoheliox”的潜在治疗作用,即通过加热的氦氧混合物呼吸,给出了理化解释。
更新日期:2020-06-01
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