Evaluation of serum uric levels in migraine.,Neurological Sciences

当前位置： X-MOL 学术 › Neurol. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Evaluation of serum uric levels in migraine.
Neurological Sciences ( IF 3.3 ) Pub Date : 2020-07-20 , DOI: 10.1007/s10072-020-04598-w
Tamer Yazar ₁ , Hülya Olgun Yazar ₂ , Ali Aygün ₃ , Volkan Karabacak ₄ , Yavuz Altunkaynak ₅ , Dursun Kirbaş ₆

Affiliation

Objective

In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine).

Method

The study included 300 migraine patients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria. Patients were evaluated during attendance at the neurology clinic.

Results

Our patient group was 77.0% female and disease duration was 9.2 ± 7.2 years. Our control group comprised 77.3% females. The age intervals in the patient and control groups were 36.4 ± 10.4 years and 36.0 ± 8.1 years. There was no statistically significant difference between our control and patient groups in terms of age and gender (p = .937 and p = .655). The serum UA, ferritin, and urea levels in our patient group were found to be significantly low compared to the healthy control group (p < .001). The serum UA levels in the migraine and control groups were 3.7 ± 0.7 and 4.6 ± 0.7 mg/dL, respectively (p < .001). There were no statistically significant differences observed between serum uric acid levels and other blood parameters between aura/without aura and episodic/chronic migraine subtypes (p > .05).

Conclusion

Our study supports the hypothesis that the oxidative stress marker of serum uric acid levels may be associated with migraine diagnosis, concluding that serum uric acid levels were not significant for migraine subtypes.

中文翻译：

偏头痛的血清尿酸水平评估。

目的

在我们的研究中，目的是根据偏头痛亚型（先兆/无先兆和发作性/慢性偏头痛）确定血清尿酸水平（氧化应激的标志）。

方法

该研究包括300位偏头痛患者和150位健康对照，共450人。偏头痛和亚型是根据《国际头痛分类》 -2013年标准诊断的。在神经内科门诊就诊时对患者进行了评估。

结果

我们的患者组为女性77.0％，病程为9.2±7.2年。我们的对照组包括77.3％的女性。患者和对照组的年龄间隔分别为36.4±10.4岁和36.0±8.1岁。在对照组和患者组之间，在年龄和性别方面无统计学差异（p = .937和p = .655）。与健康对照组相比，我们患者组的血清UA，铁蛋白和尿素水平显着降低（p <.001）。偏头痛组和对照组的血清UA水平分别为3.7±0.7和4.6±0.7 mg / dL（p <.001）。在先兆/无先兆和发作性/慢性偏头痛亚型之间，血清尿酸水平和其他血液参数之间没有统计学上的显着差异（p > .05）。