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Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD).
Journal of Neural Transmission ( IF 3.3 ) Pub Date : 2020-07-20 , DOI: 10.1007/s00702-020-02231-w
Ayla Uzun Cicek 1 , Cansu Mercan Isik 1 , Sevtap Bakir 2 , Dilara Ulger 2 , Seda Aybuke Sari 1 , Deniz Bakir 2 , Selim Cam 3
Affiliation  

Growing evidence suggests that telomeres, telomerase, matrix metalloproteinase-9 (MMP-9), and SIRT1 (sirtuin1) are involved in the pathophysiology of neuropsychiatric and neurodevelopmental disorders. However, whether these molecules are contributors to attention-deficit/hyperactivity disorder (ADHD) has been little explored and poorly understood. This study aimed to determine the potential role of telomerase, MMP-9, and SIRT1 in children with ADHD. The study was performed on 46 children with ADHD aged between 8 and 14 and 43 healthy children matching in age and gender. Children were evaluated by Kiddie-Sads-Present and Lifetime Version, Conners’ Parent Rating Scale-Revised Short Form (CPRS-RS) and Stroop test. Serum telomerase, MMP-9, and SIRT1 levels were measured by a quantitative sandwich enzyme-linked immunosorbent assay. MMP-9 and telomerase levels were significantly higher and SIRT1 levels were significantly lower in patients with ADHD than those of controls. All three molecules were significantly associated with both the severity of ADHD symptoms and cognitive functions. This is the first attempt to indicate that the important role of telomerase, MMP-9, and SIRT1 in ADHD, and the association of all these molecules with the severity of ADHD and cognitive functions, but future studies are required to verify these results.



中文翻译:

支持端粒酶、MMP-9 和 SIRT1 在注意力缺陷/多动障碍 (ADHD) 中作用的证据。

越来越多的证据表明,端粒、端粒酶、基质金属蛋白酶 9 (MMP-9) 和SIRT1 (sirtuin1) 参与了神经精神和神经发育障碍的病理生理学。然而,这些分子是否会导致注意力缺陷/多动障碍 (ADHD) 的研究很少,也知之甚少。本研究旨在确定端粒酶、MMP-9 和SIRT1在 ADHD 儿童中的潜在作用。该研究对 46 名年龄在 8 至 14 岁之间的多动症儿童和 43 名年龄和性别相匹配的健康儿童进行。通过 Kiddie-Sads-Present 和 Lifetime Version、Conners 父母评定量表修订简表 (CPRS-RS) 和 Stroop 测试对儿童进行评估。血清端粒酶、MMP-9 和SIRT1通过定量夹心酶联免疫吸附测定法测量水平。ADHD 患者的MMP-9 和端粒酶水平显着高于对照组,而SIRT1水平显着低于对照组。所有三种分子都与 ADHD 症状的严重程度和认知功能显着相关。这是首次尝试表明端粒酶、MMP-9 和SIRT1在 ADHD 中的重要作用,以及所有这些分子与 ADHD 的严重程度和认知功能的关联,但需要未来的研究来验证这些结果。

更新日期:2020-07-20
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