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Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders.
Open Biology ( IF 5.8 ) Pub Date : 2020-07-08 , DOI: 10.1098/rsob.200063
Destiny Ogbu 1 , Eric Xia 1, 2 , Jun Sun 1, 3
Affiliation  

The gut microbiome regulates a relationship with the brain known as the gut–microbiota–brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in autism spectrum disorder (ASD) as well as attention deficit hyperactivity disorder (ADHD). There are previously established negative correlations among vitamin D, vitamin D receptor (VDR) levels and severity of ASD as well as ADHD. Both vitamin D and VDR are known to regulate homeostasis in the brain and the intestinal microbiome. This review summarizes the growing relationship between vitamin D/VDR signalling and the GMB axis in ASD and ADHD. We focus on current publications and summarize the progress of GMB in neurodevelopmental disorders, describe effects and mechanisms of vitamin D/VDR in regulating the microbiome and synoptically highlight the potential applications of targeting vitamin D/VDR signalling in neurodevelopment disorders.



中文翻译:

肠道本能:神经发育障碍中的维生素 D/维生素 D 受体和微生物组。

肠道微生物群调节与大脑的关系,称为肠道-微生物群-大脑 (GMB) 轴。这种相互作用受免疫细胞、微生物代谢物和神经递质的影响。最近的研究结果表明,肠道菌群失调在自闭症谱系障碍 (ASD) 和注意力缺陷多动障碍 (ADHD) 中很普遍。先前已确定维生素 D、维生素 D 受体 (VDR) 水平与 ASD 和 ADHD 的严重程度之间存在负相关。众所周知,维生素 D 和 VDR 都可以调节大脑和肠道微生物群的稳态。本综述总结了 ASD 和 ADHD 中维生素 D/VDR 信号与 GMB 轴之间日益增长的关系。我们专注于当前的出版物并总结 GMB 在神经发育障碍中的进展,

更新日期:2020-07-20
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