The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.

中文翻译：

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T细胞库分子表征的过去和未来：Eli Sercarz贡献的一些亮点

Eli E. Sercarz对免疫学和免疫病理学的贡献非常显着，并且在理解微调免疫反应机理的过程中取得了许多里程碑。他的一部分工作致力于研究淋巴细胞T细胞库的深层复杂性及其在生理发育和疾病中的重要性，例如T细胞反应的克隆异质性。从这些研究开始，在他的指导下，我们有机会实施光谱分型方法，并将其应用于人类和实验性自身免疫性疾病，获得了有趣的结果。这篇简短回顾的开放性问题是，在大数据和组学时代，这种精细而复杂的技术（免疫镜分析）可能发挥的作用。