CRISPR/Cas9 is an innovative molecular tool that is utilized in advanced biological applications. This review focuses on modifying the genomes of a wide range of animals by CRISPR/Cas9 for greater usability and higher efficiency, providing an overview of the function and mechanism of this system and the utilization of this system for medicinal research. The type II CRISPR-Cas system is found in the Enterobacteriaceae bacteria family, which uses this system as a defense against invading phages and plasmids. This system can be engineered to direct its action toward a targeted site for the modification of a specific genome.

中文翻译：

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CRISPR / Cas：动物模型中基因组编辑的成功工具。

CRISPR / Cas9是一种创新的分子工具，可用于高级生物学应用。这篇综述着重于通过CRISPR / Cas9修饰各种动物的基因组，以提高可用性和效率，概述该系统的功能和机制，以及将该系统用于医学研究。在肠杆菌科细菌家族中发现了II型CRISPR-Cas系统，该系统使用该系统来防御入侵的噬菌体和质粒。可以对该系统进行改造，使其作用指向针对特定基因组修饰的目标位点。