当前位置: X-MOL 学术Indian J. Chem. Sect. B › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis, characterization, molecular docking studies and biological activity ofcoumarin linked 2-pyridone heterocycles
Indian Journal of Chemistry, Section B ( IF 0.456 ) Pub Date : 2020-02-11
Nisheeth C Desai, Tushar J Karkar, Rajesh H Vekariya, Surbhi B Joshi, Krunalsinh A Jadeja, Darshita V Vaja

In the present paper, the synthesis, characterization, antimicrobial activity and in silico molecular docking study of6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structuredetermination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed thatbiological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para positionplays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at paraposition for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From thecytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity.




中文翻译:

香豆素连接的2-吡啶酮杂环的合成,表征,分子对接研究和生物活性

本文研究了6-((亚芳基)氨基)-4-(4-氯苯基)-2-氧代-1-((1-(2-氧代-)的合成,表征,抗菌活性和计算机分子对接研究据报道有2H-铬-3-基)亚乙基)氨基)-1,2-二氢吡啶-3,5-二腈4a-o。化合物4d,4g,4j,4k,4m和4o显示出明显的活性。合成化合物的结构测定已通过标准光谱技术完成。观察到生物活性受分子的电子环境影响。在对位的吸电子基团起着增强抗菌活性的生物活性的作用,而在对位的吸电子基团起到抗真菌活性的作用。化合物4a-o已经进一步评估了对HeLa细胞的细胞毒性。从细胞毒性结果来看,


更新日期:2020-02-11
down
wechat
bug