The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2.,For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.,The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus.,The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.

中文翻译：

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胆囊结石药物溶出可能性的研究

本文的目的是验证使用常规超声频率和强度从 0.1 到 0.5 W/cm2 超声增强胆囊胆固醇结石药物溶解的可能性。出于研究目的，开发了含有猪胆汁的物理模型，猪肝、猪皮、脂肪和肌肉，以及手术切除的人体胆固醇结石和熊去氧胆酸药物。研究表明超声照射有可能加速胆囊结石的药物溶解。0.4 W/cm2的超声强度对增强结石溶解效果最好。研究结果将用于推进胆囊结石药物溶解超声增强装置和方法的开发。