Neonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex‐specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1–10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole‐board task, increased Na+/K+‐ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non‐handled males. Female neonatal handled animals increased the number of rearing and nose‐pokes on the hole‐board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non‐handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex‐specific manner even before the puberty onset.

中文翻译：

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早期生活压力对雄性和雌性幼年 Wistar 大鼠的行为和神经化学参数的影响不同

新生儿处理是早期生活压力源，它以性别特异性方式导致成年大鼠的行为和神经化学变化，并可能影响发育的早期阶段。在这里，我们研究了新生儿处理（出生后 1-10 天）对断奶后幼鼠的生化参数和嗅觉记忆的影响。与未处理的雄性相比，处理过的雄性新生大鼠在洞板任务中进行了更多的交叉，增加了嗅球中的 Na+/K+-ATP 酶活性，并降低了海马中的乙酰胆碱酯酶活性。与未处理的雌性相比，处理过雌性新生儿的动物在洞板任务中增加了饲养和戳鼻子的次数，降低了谷胱甘肽过氧化物酶的活性，以及​​海马体中的总硫醇含量。