Peri‐ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic‐clonic seizures,Epilepsia

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Peri‐ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic‐clonic seizures
Epilepsia ( IF 5.6 ) Pub Date : 2020-07-19 , DOI: 10.1111/epi.16615
Luke A Allen _{1,

2,

3} , Ronald M Harper _{3,

4,

5} , Sjoerd B Vos _{3,

6,

7} , Catherine A Scott _{1,

3,

8} , Nuria Lacuey _{3,

9} , Laura Vilella _{3,

9} , Joel S Winston ₁ , Benjamin P Whatley ₁ , Rajesh Kumar _{3,

5,

10} , Jennifer Ogren _{3,

4,

5} , Jaison S Hampson ₉ , Sandhya Rani ₉ , Gavin P Winston _{1,

2,

11} , Louis Lemieux ₁ , Samden D Lhatoo _{3,

9} , Beate Diehl _{1,

3,

8}

Affiliation

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, London, UK.
Epilepsy Society MRI Unit, Chalfont St Peter, UK.
The Center for SUDEP Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
UCLA Brain Research Institute, Los Angeles, CA, USA.
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Centre for Medical Image Computing, University College London, London, UK.
Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, UK.
Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, UCLH, London, UK.
Department of Neurology, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Department of Anaesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Division of Neurology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Hypoxia, or abnormally low blood‐oxygen levels, often accompanies seizures and may elicit brain structural changes in people with epilepsy which contribute to central processes underlying sudden unexpected death in epilepsy (SUDEP). The extent to which hypoxia may be related to brain structural alterations in this patient group remains unexplored.

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