当前位置: X-MOL 学术Pharmacol. Therapeut. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2020-07-18 , DOI: 10.1016/j.pharmthera.2020.107633
Miaomiao Ye 1 , Yizuo Song 1 , Shuya Pan 1 , Man Chu 2 , Zhi-Wei Wang 3 , Xueqiong Zhu 1
Affiliation  

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix (ECM) and the cross-linking of collagen and elastic fibers. Recently, a growing body of research has demonstrated that LOX family is critically involved in the regulation of cancer cell proliferation, migration, invasion and metastasis. In this review, we discuss the roles of LOX family members in the development and progression of different types of human cancers. Furthermore, we also describe the potential inhibitors of LOX family proteins and highlight that LOX family might be an important therapeutic target for cancer therapy.



中文翻译:

赖氨酰氧化酶家族在肿瘤发生和癌症治疗中的作用不断演变。

赖氨酰氧化酶 (LOX) 家族由 LOX 和四种 LOX 样蛋白 (LOXL1、LOXL2、LOXL3 和 LOXL4) 组成,主要作用于细胞外基质 (ECM) 的重塑以及胶原和弹性纤维的交联. 最近,越来越多的研究表明,LOX 家族与癌细胞增殖、迁移、侵袭和转移的调节密切相关。在这篇综述中,我们讨论了 LOX 家族成员在不同类型人类癌症的发展和进展中的作用。此外,我们还描述了 LOX 家族蛋白的潜在抑制剂,并强调 LOX 家族可能是癌症治疗的重要治疗靶点。

更新日期:2020-07-29
down
wechat
bug