GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.

GSK3 参与不同的身体和病理状况，巨噬细胞调节的炎症有助于重要机制。感染刺激可能调节 GSK3 活性并影响宿主细胞适应、免疫细胞浸润或细胞因子表达。为进一步阐述 GSK3 调节在巨噬细胞中的作用，简要介绍了内毒素、病毒和遗传因素挑战的三大器官（肺损伤、心肌炎和常染色体显性多囊肾病）的信号转导。由于GSK3在不同微环境和巨噬细胞阶段（M1/M2）的促炎和抗炎作用，应充分考虑GSK3的合理解决。