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SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection.
Science Immunology ( IF 24.8 ) Pub Date : 2020-07-17 , DOI: 10.1126/sciimmunol.abd6160
Daniel M Altmann 1 , Rosemary J Boyton 2, 3
Affiliation  

In efforts to synthesize a clear understanding of SARS-CoV-2 protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild and severe COVID-19. Defining CD4 and CD8 effector functions in protection is important considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.



中文翻译:

SARS-CoV-2 T细胞免疫力:特异性,功能,耐用性和保护作用。

为了对SARS-CoV-2保护性免疫产生清晰的理解,抗体分析与无症状,轻度和严重COVID-19的T细胞研究同时进行。考虑到抗体应答的寿命很短,而T细胞的记忆力可能更持久,因此定义CD4和CD8效应子的保护功能非常重要。为了充分了解人群水平的免疫力,使用标准化测试方法筛查抗体和T细胞免疫力将是有益的。

更新日期:2020-07-18
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