Statement of problem

Immunosuppression and coinfections associated with human immunodeficiency virus (HIV) infection pose a relative contraindication for dental implant therapy. However, although implants have been placed in patients with HIV with reasonable success, how HIV infection affects their survival is unclear.

Purpose

The purpose of this systematic review of the literature and meta-analysis was to analyze the data on the survival of dental implants in patients with HIV.

Material and methods

A search for relevant articles published up to November 2019 was performed in PubMed/Medline and Cochrane databases, Clinicaltrials.gov, and Google Scholar. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted for the conduct of the systematic review. The most pertinent data were extracted and pooled for qualitative and quantitative analyses with 95% confidence intervals. Heterogeneity was analyzed by using I-squared statistics.

Results

A total of 8 studies involving 411 individuals with HIV and 1109 implants were included in the meta-analysis. The mean follow-up period was 2.8 years. A pooled estimate of 95% of implant survival rate with 95% confidence interval(92% to 96%) was noted. Heterogeneity across the 8 studies was found to be 41% with moderate true variability.

Conclusions

This systematic review demonstrated that HIV infection does not pose a serious threat to implant survival on short-term evaluation, but the evidence is of low quality.

中文翻译：

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HIV 感染会影响种植牙的存活率吗？系统评价和荟萃分析

问题陈述

与人类免疫缺陷病毒 (HIV) 感染相关的免疫抑制和合并感染是种植牙治疗的相对禁忌症。然而，尽管在 HIV 患者中植入植入物并取得了一定的成功，但 HIV 感染如何影响他们的生存尚不清楚。

目的

对文献和荟萃分析进行系统回顾的目的是分析 HIV 患者种植牙存活率的数据。

材料与方法

在 PubMed/Medline 和 Cochrane 数据库、Clinicaltrials.gov 和 Google Scholar 中搜索了截至 2019 年 11 月发表的相关文章。系统评价和荟萃分析的首选报告项目指南被用于进行系统评价。提取并汇总最相关的数据，以 95% 的置信区间进行定性和定量分析。异质性分析采用 I 方统计。

结果

荟萃分析共纳入了 8 项研究，涉及 411 名 HIV 感染者和 1109 个植入物。平均随访时间为 2.8 年。注意到 95% 的置信区间（92% 至 96%）的种植体存活率的汇总估计值。发现 8 项研究的异质性为 41%，具有中等真实变异性。

结论

该系统评价表明，在短期评估中，HIV 感染不会对植入物存活构成严重威胁，但证据质量较低。