Abstract Irrigant solutions used during and after endodontic treatment on the dentinal surface can influence the bond strength of glass-fibre posts. The aim of this systematic review was to provide an overview of available scientific evidence on the influence of endodontic irrigants on glass-fibre post bond strength. This review followed the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To identify relevant papers, an electronic search was conducted in PubMed, Cochrane, Elsevier, Scopus and EBSCO databases. There were no language restrictions and the last search was conducted to include studies published up to and including July 1, 2019. We searched for in vitro or ex vivo studies that included human or bovine specimens and reported on dentin-fibre post bond strength with the use of different irrigants for root canals. Common variables were identified to consolidate the data, such as bond strength values, interface failure mode and microstructural changes in the dentin after treatments. From 79 potentially relevant papers identified from the database searches, 19 were included in our study for full-text analysis. Authors of this review independently screened search results, extracted data and assessed the risk of bias. Data heterogeneity was present, with differences in dentin type, bond strength tests and irrigation and luting protocols. Current findings suggest that dentin bonding is adversely affected by 5.25% sodium hypochlorite (NaOCl). Chelators adversely affect bonding to root dentin. Antioxidant agents could recover the bond strength between the glass-fibre post and the dentin. Conditioning with phosphoric acid (H3PO4) and NaOCl/ethylenediaminetetraacetic acid (EDTA) with ultrasonic agitation might be recommended in order to remove the smear layer and produce an adequate resin-tag formation. Ageing affects resin cement-dentin bond strength by degradation of collagen fibrils resulting from the activation of endogenous proteases. Therefore, ethanol (EtOH), chlorhexidine (CHX), or cross-linkers can be used to inhibit the activity of matrix metalloproteinases (MMPs) and maintain bond strength over time to achieve greater and longer-term stability of the bonding interface. There are difficulties in achieving an effective resin-root dentin bond. Therefore, this review is clinically significant because recognising the effects of root canal irrigating substances on the retention of glass-fibre posts is essential to improve the prognosis of endodontically treated tooth restorations.

中文翻译：

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牙髓冲洗剂对玻璃纤维桩与牙本质结合强度的影响：体外研究的系统评价

摘要 在牙本质表面进行牙髓治疗期间和之后使用的冲洗液会影响玻璃纤维桩的粘合强度。本系统评价的目的是提供有关牙髓冲洗剂对玻璃纤维后粘合强度影响的现有科学证据的概述。本次审查遵循了系统评价和元分析的首选报告项目 (PRISMA) 指南。为了识别相关论文，在 PubMed、Cochrane、Elsevier、Scopus 和 EBSCO 数据库中进行了电子搜索。没有语言限制，最后一次检索包括截至 2019 年 7 月 1 日（含）发表的研究。我们搜索了包括人类或牛标本在内的体外或离体研究，并报告了使用不同根管冲洗剂后牙本质纤维粘合后的强度。确定了共同变量以巩固数据，例如粘合强度值、界面破坏模式和治疗后牙本质的微观结构变化。从数据库搜索中确定的 79 篇可能相关的论文中，有 19 篇被纳入我们的研究进行全文分析。本综述的作者独立筛选搜索结果、提取数据并评估偏倚风险。存在数据异质性，牙本质类型、粘合强度测试以及冲洗和粘合方案存在差异。目前的研究结果表明，5.25% 的次氯酸钠 (NaOCl) 会对牙本质粘合产生不利影响。螯合剂不利地影响与根牙本质的结合。抗氧化剂可以恢复玻璃纤维桩和牙本质之间的粘合强度。可能建议使用磷酸 (H3PO4) 和 NaOCl/乙二胺四乙酸 (EDTA) 进行调理，同时超声搅拌，以去除涂抹层并形成足够的树脂标签。老化通过内源性蛋白酶激活导致的胶原纤维降解来影响树脂粘固剂与牙本质的结合强度。因此，乙醇 (EtOH)、氯己定 (CHX) 或交联剂可用于抑制基质金属蛋白酶 (MMP) 的活性并随着时间的推移保持粘合强度，以实现粘合界面的更大和更长期的稳定性。实现有效的树脂-牙根牙本质粘合存在困难。所以，