As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These biological processes produce mechanical forces that further shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact biochemical and genetic programs of development. This gap in knowledge stems from a lack of understanding of the molecular players of cellular mechanics and an absence of techniques for measuring and manipulating mechanical forces in tissue. In this review article, we examine recent advances that are beginning to clear these bottlenecks and highlight results from new approaches that reveal the role of mechanical forces in neurodevelopmental processes.

随着大脑的发育，增殖细胞组织成结构、分化、迁移、挤出长突起并与其他细胞连接。这些生物过程产生机械力，进一步塑造细胞动力学和器官模式。发育生物学中一个未解决的主要问题是发育过程中产生的机械力如何被细胞检测和转导以影响发育的生化和遗传程序。这种知识差距源于对细胞力学的分子参与者缺乏了解，以及缺乏测量和操纵组织中机械力的技术。在这篇评论文章中，