A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

中文翻译：

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元素硼纳米颗粒：在水介质中超声制备及其在硼中子俘获疗法中的应用

描述了一种通过在液体介质中超声分散和随后的级联分馏来生产尺寸小于 100 nm 的元素硼纳米粒子的方法。所得的硼纳米粒子被用作硼中子俘获疗法（BNCT）的靶标。根据 BNCT 与合成的硼纳米粒子的临床前实验研究结果，将 T98G 人神经胶质瘤细胞在含有硼纳米粒子（10、20 和 40 ppm，以硼-10 为单位）的培养基中进行中子照射 1 小时同位素）导致细胞活力的显着抑制。