A highly efficient and straightforward one-pot three-component synthesis of functionalized 2-amino-4H-chromenes and indole-substituted 3-amino-1H-benzo[f]chromenes have been developed by 3-amino-1,2,4-triazole supported on hydroxyapatite-encapsulated-γ-Fe₂O₃ (γ-Fe₂O₃@HAp@CPTMS@AT) as the new magnetically recyclable heterogeneous basic nanocatalyst. The wide range of valuable 4H-chromene and 1H-chromene structures having different substituents were efficiently synthesized using one-pot tandem Knoevenagel cyclocondensation reaction of aromatic aldehydes, active methylene nitriles (malononitrile and 3-cyanoacetylindole) and diverse phenolic nucleophiles (resorcinol, α-naphthol and β-naphthol) in the presence of nano γ-Fe₂O₃@HAp@CPTMS@AT in EtOH. The structure and morphology of the synthesized nanocatalyst were characterized by using various techniques such as FT-IR, FESEM, EDS, XRD, TGA-DTA and VSM. The catalytic activity of nano γ-Fe₂O₃@HAp@CPTMS@AT was evaluated and the results indicated its applicability as a novel, highly efficient, green, recyclable and promising heterogeneous basic nanocatalyst for the synthesis of 4H-chromene and 1H-chromene derivatives.

3-氨基-1,2已开发出一种功能强大的2-氨基-4 H-色烯和吲哚取代的3-氨基-1 H-苯并[ f ]色烯的高效，简单的一锅三组分合成方法， 4三唑支撑在羟基磷灰石包封-γ-的Fe ₂ ö ₃（γ-的Fe ₂ ö ₃ @的HAp @ CPTMS @ AT）作为新的磁可回收异构基本纳米催化剂。多种有价值的4 H-色烯和1 H在芳香族醛，活性亚甲基腈（丙二腈和3-氰基乙酰吲哚）和各种酚类亲核试剂（间苯二酚，α-萘酚和β-萘酚）存在下，通过一锅串联Knoevenagel环缩合反应可有效合成具有不同取代基的亚甲基苯甲醛结构纳米了γ-Fe ₂ ö ₃ @的HAp @ CPTMS @ AT在EtOH。通过FT-IR，FESEM，EDS，XRD，TGA-DTA和VSM等多种技术对合成的纳米催化剂的结构和形貌进行了表征。的纳米催化活性γ-的Fe ₂ ö ₃ @的HAp @ CPTMS @ AT进行了评价，结果表明其适用性作为一种新型的，高效率的，绿色的，可回收和有前途的非均相基本为纳米催化剂合成4H-色烯和1个H-色烯衍生物。