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Sensitive detection of clenbuterol by hybrid iridium/silicon nanowire-enhanced laser desorption/ionization mass spectrometry.
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2020-07-17 , DOI: 10.1039/d0tb00186d
Rui Lv 1 , Enhui Wu , Renfei Wu , Wen Shen , Chongqing Ma , Rui Shi , Ruochen Guo , Mingwang Shao , Jian Liu
Affiliation  

There is increasing demand for anti-doping drug monitoring in sports and food safety checks by developing sensitive and fast analytical methods. Here we report the development of hybrid Ir/SiNW as a new MALDI matrix for the detection of small molecules. This matrix is characterized by sufficient UV absorption, low-noise background, and high efficiency in ionization of small molecules. Sensitive detection of clenbuterol (LOD: 0.18 pmol) and a variety of other small molecules has been achieved using the Ir/SiNW matrix with a reproducible performance. Compared to the individual components separately, the matrix of hybrid Ir/SiNW synthesized via in situ growth can promote the MS signal intensity by up to 10 fold under identical experimental conditions. We provide a unique mechanism for the high performance of the hybrid Ir/SiNW matrix with the characteristic properties of hydrogen atom transfer and enhanced protonation at the interface of the hybrid nanostructures. Our approach of using a hybrid Ir/SiNW matrix enables detection of clenbuterol quantitatively in complicated biological samples and in vivo experiments, promising a useful tool for food security and anti-doping drug monitoring in sports.

中文翻译:

混合铱/硅纳米线增强激光解吸/电离质谱法灵敏检测盐酸克伦特罗。

通过开发灵敏,快速的分析方法,在运动和食品安全检查中对反兴奋剂药物监测的需求不断增长。在这里,我们报告混合Ir / SiNW的发展,作为检测小分子的新MALDI矩阵。该基质的特点是具有足够的紫外线吸收,低噪声背景和小分子电离的高效率。使用具有可重现性能的Ir / SiNW基质已经实现了克仑特罗(LOD:0.18 pmol)和多种其他小分子的灵敏检测。与单独的成分相比,通过原位合成的Ir / SiNW杂化基质在相同的实验条件下,生长可以将MS信号强度提高多达10倍。我们为杂化Ir / SiNW基质的高性能提供了独特的机制,具有杂化纳米结构界面处氢原子转移和增强质子化的特征。我们使用混合Ir / SiNW基质的方法能够定量检测复杂的生物样品和体内实验中的盐酸克伦特罗,有望成为体育食品安全和反兴奋剂监测的有用工具。
更新日期:2020-09-02
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