Time is brain when it comes to door-to-needle times for acute ischaemic stroke, right? A retrospective study of 61 426 people aged over 65 treated with intravenous tissue plasminogen activator shows that long delays before therapy are significantly associated with higher all-cause mortality at a year and higher likelihood of all-cause readmission at a year. With every increase in 15 min, the hazard-ratio increases by 1.02. In this study, 5.6% were treated within half an hour and 37.5% after 75 min. The authors conclude that therapy within 45 min is optimum. JAMA. 2020;323(21):2170–2184. Providing career advice used to be simple, it was like …

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岩相学

说到急性缺血性卒中的门到针时间，时间就是大脑，对吗？一项对61 426名65岁以上的65岁以上人群进行静脉组织纤溶酶原激活剂治疗的回顾性研究表明，治疗前长时间的拖延与每年更高的全因死亡率和每年更高的全因再入院率显着相关。每增加15分钟，危险比率就会增加1.02。在这项研究中，半小时内治疗了5.6％，75分钟后治疗了37.5％。作者得出结论，在45分钟内进行最佳治疗。贾玛 2020; 323（21）：2170-2184。提供职业建议曾经很简单，就像……