Gastric cancer (GC), one of the most common cancers in gastrointestinal malignant tumors. Long noncoding RNAs were widely reported to play a significant role in the regulation of occurrence or development of tumors. Bioinformatics analysis and a wide range of experiments were conducted to explore the expression status, specific function and molecular mechanism of long noncoding RNA ABHD11-AS1. ABHD11-AS1 knockdown repressed cell proliferation but enhanced cell apoptosis in function. We proved that miR-361-3p directly combine with the 3’UTR of PDPK2 and ABHD11-AS1 cooperated with miR-361-3p to modulate PDPK2 mRNA and protein levels. Rescue assays confirmed that the miR-361-3p silence reversed the suppressive effect of ABHD11-AS1 deficiency. In summary, ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p/PDPK1 signaling.

中文翻译：

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长非编码RNA ABHD11-AS1通过调节miR-361-3p / PDPK1信号传导促进胃癌的发展。

胃癌（GC），是胃肠道恶性肿瘤中最常见的癌症之一。广泛报道长的非编码RNA在调节肿瘤的发生或发展中起重要作用。进行了生物信息学分析和广泛的实验，以探讨长非编码RNA ABHD11-AS1的表达状态，特异性功能和分子机制。ABHD11-AS1组合式抑制细胞增殖，但增强细胞凋亡的功能。我们证明miR-361-3p直接与PDPK2的3'UTR结合，ABHD11-AS1与miR-361-3p协同调节PDPK2 mRNA和蛋白水平。救援试验证实，miR-361-3p沉默沉默逆转了ABHD11-AS1缺乏的抑制作用。总之，ABHD11-AS1通过调节miR-361-3p / PDPK1信号传导促进胃癌的发展。