In our study, Lifetime cancer prevalence and life history traits in mammals, we reported the prevalence of neoplasia and malignancy in a select group of mammals housed at San Diego Zoo Global from 1964 to 1978 and 1987 to 2015 [1]. We also used these data to evaluate associations between life history traits and measures of population health. Our analysis showed placental invasiveness could not predict the proportion of animals diagnosed with neoplasia or malignancy. In a response to our article, Drs Wagner and colleagues describe a different calculation to test for a relationship between placental invasiveness and malignancy. They identified and included previously published veterinary neoplasia and malignancy data with our published dataset and suggest a positive relationship between placental invasiveness and development of malignancy (referred to as malignancy rate in Wagner and colleagues’ response). These data provided support for the Evolved Levels of Invasiveness (ELI) hypothesis [2]. We are pleased that other investigators find our data useful, and wholeheartedly agree with Drs Wagner and colleagues in the need to identify more data on cancer in a wide variety of species. Notwithstanding, this updated analysis brings up a number of topics that we would like to address.

中文翻译：

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胎盘侵袭性会导致哺乳动物恶性转化率更高吗？回复：“现有数据表明胎盘浸润与恶性肿瘤之间呈正相关”

在我们的研究中，哺乳动物的终生癌症流行率和生活史特征，我们报道了1964年至1978年以及1987年至2015年间在圣地亚哥动物园全球饲养的一组特定哺乳动物中的瘤形成和恶性肿瘤的患病率[1]。我们还使用这些数据来评估生活史特征与人口健康度量之间的关联。我们的分析表明，胎盘浸润不能预测诊断为肿瘤或恶性肿瘤的动物比例。在回应我们的文章时，Wagner博士及其同事描述了一种不同的计算方法，以测试胎盘浸润性与恶性肿瘤之间的关系。他们确定了先前发表的兽医肿瘤和恶性肿瘤数据，并将其与我们发表的数据集包括在内，并暗示胎盘浸润性与恶性肿瘤发展之间存在正相关（在Wagner和同事的反应中称为恶性肿瘤率）。这些数据为进化的入侵水平（ELI）假说提供了支持[2]。我们很高兴其他研究人员发现我们的数据有用，并全心同意Wagner博士及其同事的观点，他们需要确定更多有关各种物种的癌症数据。尽管如此，此更新的分析提出了许多我们要解决的主题。