ABSTRACT

Birth during pollen seasons may influence food allergy risk but no study has assessed pollen exposure. Using the HealthNuts population-based cohort of 5276 infants, we assessed grass pollen exposures, in utero and up to the first 6 months of life, on hen’s egg, sesame and peanut allergy outcomes at 12 months. Cumulative pollen exposure in the first 7 days of life increased risk of peanut sensitization aMOR (adjusted multinomial odds ratio) = 1.21 (95% CI: 1.01–1.44). Exposure between first 4–6 months of life increased risk of hen’s egg aMOR = 1.02 (95% CI: 1.004–1.04) and sensitization to all foods aMOR = 1.02 (95% CI: 1.003–1.04). Grass pollen exposure was associated with food challenge diagnosed food allergy, but only among infants with a maternal history of food allergy. Exposure to grass pollen in the intrauterine period and infancy may be important but more studies are needed to replicate these findings.

摘要

在花粉季节出生可能会影响食物过敏风险，但没有研究评估花粉暴露。使用基于 HealthNuts 人群的 5276 名婴儿队列，我们​​评估了在子宫内和生命的前 6 个月内草花粉暴露对 12 个月时鸡蛋、芝麻和花生过敏结果的影响。生命前 7 天的累积花粉暴露增加了花生致敏风险 aMOR（调整后的多项优势比）= 1.21（95% CI：1.01-1.44）。出生后 4-6 个月之间的接触增加了鸡蛋 aMOR = 1.02（95% CI：1.004-1.04）和对所有食物过敏 aMOR = 1.02（95% CI：1.003-1.04）的风险。草花粉暴露与食物挑战诊断的食物过敏有关，但仅在有母亲食物过敏史的婴儿中。接触草花粉宫内期和婴儿期可能很重要，但需要更多的研究来复制这些发现。