Emerging evidence suggests that extracellular matrix (ECM) alterations occur with stress. Specifically, increases in perineuronal net (PNN) deposition have been observed in rodents exposed to chronic corticosterone or persistent social defeat stress. The PNN is a specific form of ECM that is predominantly localized to parvalbumin (PV)-expressing inhibitory interneurons where it modulates neuronal excitability and brain oscillations that are influenced by the same. Consistent with a role for ECM changes in contributing to the depressive phenotype, recent studies have demonstrated that monoamine reuptake inhibitor type antidepressants can reduce PNN deposition, improve behavior and stimulate changes in gamma oscillatory power that may be important to mood and memory. The present review will highlight studies in humans, rodents and zebrafish that have examined stress, PNN deposition and/or gamma oscillations with a focus on potential cellular and molecular underpinnings.

中文翻译：

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伴随压力和抑郁的细胞外基质重塑：对人类、啮齿动物和斑马鱼模型的研究

新出现的证据表明，细胞外基质 (ECM) 的改变会随着压力而发生。具体而言，在暴露于慢性皮质酮或持续社交失败压力的啮齿动物中观察到神经周围网 (PNN) 沉积增加。PNN 是一种特定形式的 ECM，主要定位于表达小清蛋白 (PV) 的抑制性中间神经元，在那里它调节受其影响的神经元兴奋性和大脑振荡。与 ECM 变化在导致抑郁表型中的作用一致，最近的研究表明，单胺再摄取抑制剂类型的抗抑郁药可以减少 PNN 沉积、改善行为并刺激可能对情绪和记忆很重要的伽马振荡能力的变化。本综述将重点介绍对人类的研究，