Guillain‐Barré syndrome (GBS) is an inflammatory polyradiculoneuropathy associated with numerous viral infections. Recently, there have been many case reports describing the association between coronavirus disease‐2019 (COVID‐19) and GBS, but much remains unknown about the strength of the association and the features of GBS in this setting. We reviewed 37 published cases of GBS associated with COVID‐19 to summarize this information for clinicians and to determine whether a specific clinical or electrodiagnostic (EDx) pattern is emerging. The mean age (59 years), gender (65% male), and COVID‐19 features appeared to reflect those of hospitalized COVID‐19 patients early in the pandemic. The mean time from COVID‐19 symptoms to GBS symptoms was 11 days. The clinical presentation and severity of these GBS cases was similar to those with non–COVID‐19 GBS. The EDx pattern was considered demyelinating in approximately half of the cases. Cerebrospinal fluid, when assessed, demonstrated albuminocytologic dissociation in 76% of patients and was negative for severe acute respiratory distress syndrome–coronavirus‐2 (SARS‐CoV‐2) in all cases. Serum antiganglioside antibodies were absent in 15 of 17 patients tested. Most patients were treated with a single course of intravenous immunoglobulin, and improvement was noted within 8 weeks in most cases. GBS‐associated COVID‐19 appears to be an uncommon condition with similar clinical and EDx patterns to GBS before the pandemic. Future studies should compare patients with COVID‐19–associated GBS to those with contemporaneous non–COVID‐19 GBS and determine whether the incidence of GBS is elevated in those with COVID‐19.

中文翻译：

---

COVID-19 相关的格林-巴利综合征：早期的大流行经历。

格林巴利综合征 (GBS) 是一种与多种病毒感染相关的炎性多发性神经根神经病。最近，有许多病例报告描述了冠状病毒病‐2019 (COVID‐19) 与 GBS 之间的关联，但关于这种关联的强度和 GBS 在这种情况下的特征仍有很多未知之处。我们回顾了 37 例已发表的与 COVID-19 相关的 GBS 病例，为临床医生总结了这些信息，并确定是否出现了特定的临床或电诊断 (EDx) 模式。平均年龄（59 岁）、性别（65% 男性）和 COVID-19 特征似乎反映了大流行早期住院 COVID-19 患者的特征。从 COVID-19 症状到 GBS 症状的平均时间为 11 天。这些 GBS 病例的临床表现和严重程度与非 COVID-19 GBS 病例相似。在大约一半的病例中，EDx 模式被认为是脱髓鞘。经评估，脑脊液在 76% 的患者中显示出白蛋白细胞学分离，并且在所有病例中对严重急性呼吸窘迫综合征冠状病毒-2 (SARS-CoV-2) 均呈阴性。17 名测试患者中有 15 名血清抗神经节苷脂抗体缺失。大多数患者接受单一疗程的静脉注射免疫球蛋白治疗，大多数病例在 8 周内得到改善。GBS 相关的 COVID-19 似乎是一种罕见的疾病，其临床和 EDx 模式与大流行前的 GBS 相似。未来的研究应将 COVID-19 相关 GBS 患者与同时期非 COVID-19 GBS 患者进行比较，并确定 COVID-19 患者的 GBS 发病率是否升高。