Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study,Journal of Inherited Metabolic Disease

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Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study
Journal of Inherited Metabolic Disease ( IF 4.2 ) Pub Date : 2020-07-16 , DOI: 10.1002/jimd.12285
Muhammad Yasir Qureshi _{1,

2} , Marc C Patterson _{1,

3} , Vicki Clark ₄ , Jonathan N Johnson _{1,

2} , Margaret A Moutvic ₅ , Sherilyn W Driscoll ₅ , Jennifer L Kemppainen ₆ , John Huston ₇ , Jeff R Anderson ₈ , Andrew D Badley _{9,

10} , Peter J Tebben ₁₁ , Philip Wackel _{1,

2} , Devin Oglesbee ₁₂ , James Glockner ₇ , George Schreiner ₁₃ , Sundeep Dugar ₁₃ , Jillienne C Touchette ₁₄ , Ralitza H Gavrilova _{3,

6}

Affiliation

Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
Department of Clinical Genomics, Mayo Clinic, Rochester, Minnesota, USA.
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Office of Translation to Practice, Mayo Clinic, Rochester, Minnesota, USA.
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Pathology and Laboratory Medicine, Rochester, Minnesota, USA.
Epirium Bio Inc., San Diego, California, USA.
Superior Medical Experts, St. Paul, Minnesota, USA.

(+)‐Epicatechin (EPI) induces mitochondrial biogenesis and antioxidant metabolism in muscle fibers and neurons. We aimed to evaluate safety and efficacy of (+)‐EPI in pediatric subjects with Friedreich's ataxia (FRDA).

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