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Hydrogen sulfide signaling in regulation of cell behaviors.
Nitric Oxide ( IF 3.9 ) Pub Date : 2020-07-17 , DOI: 10.1016/j.niox.2020.07.002
Yuehong Wang 1 , Ruihuan Yu 1 , Lingyun Wu 2 , Guangdong Yang 1
Affiliation  

Recent advances in the biomedical importance of H2S have help us understand various cellular functions and pathophysiological processes from a new aspect. Specially, H2S has been demonstrated to play multiple roles in regulating cell behaviors, including cell survival, cell differentiation, cell senescence, cell hypertrophy, cell atrophy, cell metaplasia, and cell death, etc. H2S contributes to cell behavior changes via various mechanisms, such as histone modification, DNA methylation, non-coding RNA changes, DNA damage repair, transcription factor activity, and post-translational modification of proteins by S-sulfhydration, etc. In this review, we summarized the recent research progress on H2S signaling in control of cell behaviors and discussed the ways of H2S regulation of gene expressions. Given the key roles of H2S in both health and diseases, a better understanding of the regulation of H2S on cell behavior change and the underlying molecular mechanisms will help us to develop novel and more effective strategies for clinical therapy.



中文翻译:

硫化氢信号调节细胞行为。

H 2 S的生物医学重要性的最新进展已帮助我们从一个新的方面了解各种细胞功能和病理生理过程。特别,H 2 S已被证明在调节细胞行为,包括细胞存活,细胞分化,细胞衰老,细胞肥大,细胞萎缩,细胞化生和细胞死亡等H至扮演多重角色2小号有助于改变细胞行为通过组蛋白修饰,DNA甲基化,非编码RNA改变,DNA损伤修复,转录因子活性以及S-硫酸化对蛋白质进行翻译后修饰等各种机制。在本综述中,我们总结了最近的研究进展在H 2上S信号在控制细胞行为中的作用,并讨论了H 2 S调控基因表达的方式。鉴于H 2 S在健康和疾病中的关键作用,对H 2 S对细胞行为变化的调控及其潜在的分子机制的更好理解将有助于我们开发新的更有效的临床治疗策略。

更新日期:2020-07-21
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