BACKGROUND AND PURPOSE Although elevated fasting blood glucose (FBG) at admission is associated with poor outcome in patients with ischemic and hemorrhagic stroke, it has not been investigated in patients with cerebral venous thrombosis (CVT). We aimed to determine the correlation between elevated FBG and severity and outcome among CVT patients. METHODS Consecutive CVT patients between 2009 and 2019 were identified for this retrospective study. Patients with a history of diabetes mellitus or incomplete clinical data were excluded. Hyperglycemia was defined as FBG ≥ 6.1 mmol/L, further classified as mild (6.1-6.9 mmol/L) and severe hyperglycemia (≥7.0 mmol/L). The severity of CVT was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), CVT-related complications, and intracranial pressure. The outcome was assessed at discharge using mRS; mRS 3-6 indicated poor outcome. RESULTS Of 160 patients, 36 (22.5%) had hyperglycemia, and 24 (15%) had severe hyperglycemia. Baseline FBG positively correlated with NIHSS at admission (r = 0.55, P < .001). Patients with hyperglycemia had higher baseline mRS scores (P < .001), higher incidence of cerebral venous infarction (P = .039), intracranial hemorrhage (P = .005), coma (P < .001), and seizure (P = .010). Multivariate regression analysis revealed that patients with hyperglycemia had a higher risk of poor outcome (adjusted OR: 4.47; 95% CI: 1.05-18.95), and subgroup analysis showed that severe hyperglycemia (adjusted OR: 6.66; 95% CI: 1.35-32.81) was a stronger independent predictor of poor outcome. CONCLUSIONS Admission FBG was associated with severity of CVT, and elevated FBG is a predictor of short-term poor outcome among CVT patients.

中文翻译：

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空腹血糖升高可预测脑静脉血栓形成的非糖尿病患者的严重程度和不良预后

背景和目的 尽管入院时空腹血糖 (FBG) 升高与缺血性和出血性卒中患者的不良预后相关，但尚未在脑静脉血栓形成 (CVT) 患者中进行研究。我们旨在确定 FBG 升高与 CVT 患者的严重程度和结果之间的相关性。方法 本回顾性研究确定了 2009 年至 2019 年间连续发生的 CVT 患者。排除有糖尿病病史或临床资料不完整的患者。高血糖定义为 FBG ≥ 6.1 mmol/L，进一步分为轻度（6.1-6.9 mmol/L）和重度高血糖（≥7.0 mmol/L）。入院时使用美国国立卫生研究院卒中量表 (NIHSS)、改良 Rankin 量表 (mRS)、CVT 相关并发症和颅内压评估 CVT 的严重程度。出院时使用 mRS 评估结果；mRS 3-6 表明结果不佳。结果 160 名患者中，36 名 (22.5%) 有高血糖，24 名 (15%) 有严重高血糖。入院时基线 FBG 与 NIHSS 呈正相关（r = 0.55，P < .001）。高血糖患者的基线 mRS 评分较高 (P < .001)、脑静脉梗塞 (P = .039)、颅内出血 (P = .005)、昏迷 (P < .001) 和癫痫发作 (P = .001) 的发生率较高.010）。多变量回归分析显示，高血糖患者预后不良的风险较高（调整后OR：4.47；95% CI：1.05-18.95），亚组分析显示重度高血糖（调整后OR：6.66；95% CI：1.35-32.81） ) 是较差结果的更强的独立预测因子。结论 入院 FBG 与 CVT 的严重程度相关，