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Experimental and thermodynamic analyses of supercritical CO2-Solubility of minoxidil as an antihypertensive drug
Fluid Phase Equilibria ( IF 2.6 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.fluid.2020.112745
Gholamhossein Sodeifian , Nedasadat Saadati Ardestani , Fariba Razmimanesh , Seyed Ali Sajadian

Abstract A major challenge in the production of micro/nano-sized drug particulates is to understand the solubility behavior of the drug in a supercritical fluid (SCF). In the present study, solubility of Minoxidil, an antihypertensive drug, in SC-CO2 was measured statically under various sets of operating conditions in terms of temperature (308–338 K) and pressure (120–270 bar), leading to solubilities in the range of 0.24 × 10−6 to 3.39 × 10−6. Next, three different approaches were followed to estimate, rather than actually measure, the solubility, where models based on two equations of state (i.e., Soave–Redlich–Kwong (SRK) and Peng-Robinson (PR)) combined with either Wong-Sandler (WS) or van der Waals (vdW2) mixing rules, semi-empirical equations (Mendez-Santiago and Teja (MST), Bartle et al., Chrastil, Kumar and Johnston (K-J)), and the activity coefficient (UNIQUAC and modified Wilson models) were adopted to model the experimental data. The semi-empirical models were proved to be self-consistent upon performing the respective self-consistency tests. Eventually, results were devised to calculate estimates of the vaporization ( Δ H v a p ), solvation ( Δ H s o l ) and total enthalpies ( Δ H t o t a l ).

中文翻译:

米诺地尔作为降压药的超临界二氧化碳溶解度的实验和热力学分析

摘要 生产微/纳米尺寸药物颗粒的一个主要挑战是了解药物在超临界流体 (SCF) 中的溶解行为。在本研究中,在温度 (308–338 K) 和压力 (120–270 bar) 的各种操作条件下,对抗高血压药物米诺地尔在 SC-CO2 中的溶解度进行了静态测量,导致在 SC-CO2 中的溶解度。 0.24 × 10−6 到 3.39 × 10−6 的范围。接下来,采用三种不同的方法来估计而不是实际测量溶解度,其中基于两个状态方程(即 Soave-Redlich-Kwong (SRK) 和 Peng-Robinson (PR))的模型与 Wong- Sandler (WS) 或 van der Waals (vdW2) 混合规则、半经验方程(Mendez-Santiago 和 Teja (MST)、Bartle 等人、Chrastil、Kumar 和 Johnston (KJ)),活度系数(UNIQUAC 和修正的威尔逊模型)被用来模拟实验数据。在执行各自的自洽测试后,半经验模型被证明是自洽的。最终,设计结果以计算蒸发 (ΔH vap )、溶剂化 (Δ H sol ) 和总焓 ( Δ H 总 ) 的估计值。
更新日期:2020-11-01
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