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Palmitoylation: A new mechanism for control of NCX1 function.
Cell Calcium ( IF 4 ) Pub Date : 2020-07-17 , DOI: 10.1016/j.ceca.2020.102254
Elton Veseli 1 , Jonathan Soboloff 2
Affiliation  

A paper by Gök et al., identified Zinc Finger DHHC-Type Palmitoyltransferase 5 (zDHHC5) and Acyl-Protein Transferase 1 (APT1) as the enzymes responsible for the dynamic palmitoylation of NCX1. Palmitoylation occurs at the cell surface and increases the affinity of NCX1 for lipid rafts. Additionally, they discovered that palmitoylation controls the affinity of NCX1 for exchange inhibitory protein (XIP) and regulates intracellular calcium concentration. These findings provide new insights into endogenous control of NCX1 function and will drive future investigations directed at understanding its full potential.



中文翻译:

Palmitoylation:一种控制 NCX1 功能的新机制。

Gök 等人的一篇论文确定锌指 DHHC 型棕榈酰转移酶 5 (zDHHC5) 和酰基蛋白转移酶 1 (APT1) 是负责 NCX1 动态棕榈酰化的酶。棕榈酰化发生在细胞表面并增加 NCX1 对脂筏的亲和力。此外,他们发现棕榈酰化控制 NCX1 对交换抑制蛋白 (XIP) 的亲和力并调节细胞内钙浓度。这些发现为 NCX1 功能的内源性控制提供了新的见解,并将推动未来旨在了解其全部潜力的研究。

更新日期:2020-07-25
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