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SERS-based rapid detection of 2,4-dichlorophenoxyacetic acid in food matrices using molecularly imprinted magnetic polymers
Microchimica Acta ( IF 5.7 ) Pub Date : 2020-07-17 , DOI: 10.1007/s00604-020-04408-2
Yi Xu 1 , Md Mehedi Hassan 1 , Shujat Ali 1 , Huanhuan Li 1 , Quansheng Chen 1
Affiliation  

In order to remove the limitations of natural antibodies or enzymes, a nano-magnetic biomimetic platform based on a surface-enhanced Raman scattering (SERS) sensor has been developed for highly sensitive capture and detection of 2,4-dichlorophenoxyacetic acid (2,4-D) in food and water samples. Magnetic-based molecular imprinted polymer nanoparticles (Mag@MIP NPs) were constructed to capture the target 2,4-D molecule via biomimetic recognition, and gold nanoparticles (Au NPs) served as SERS-based probes, which are bound to the Mag@MIP NPs by electrostatic adsorption. The as-prepared SERS-MIP sensor for sensing of 2,4-D achieved a good linear relationship with a low detection limit (LOD) of 0.00147 ng/mL within 2 h and exhibited high sensitivity. The sensor was successfully applied to detect 2,4-D in milk and tap water and achieved good recoveries ranging from 93.5 to 102.2%. Moreover, the designed sensor system exhibited satisfactory results (p > 0.05) compared to HPLC by validation analysis. Hence, the findings demonstrated that the proposed method has significant potential for practical application in food safety and environmental protection. Graphical abstract . .

中文翻译:

使用分子印迹磁性聚合物基于 SERS 快速检测食品基质中的 2,4-二氯苯氧乙酸

为了消除天然抗体或酶的局限性,开发了一种基于表面增强拉曼散射 (SERS) 传感器的纳米磁性仿生平台,用于高度灵敏地捕获和检测 2,4-二氯苯氧乙酸 (2,4 -D) 在食物和水样品中。构建了基于磁性的分子印迹聚合物纳米粒子 (Mag@MIP NPs) 以通过仿生识别捕获目标 2,4-D 分子,金纳米粒子 (Au NPs) 作为基于 SERS 的探针,与 Mag@ 结合MIP NPs 通过静电吸附。所制备的用于检测 2,4-D 的 SERS-MIP 传感器在 2 小时内实现了良好的线性关系,低检测限 (LOD) 为 0.00147 ng/mL,并表现出高灵敏度。该传感器成功应用于检测2,在牛奶和自来水中进行 4-D 处理,获得了 93.5% 至 102.2% 的良好回收率。此外,通过验证分析,与 HPLC 相比,设计的传感器系统表现出令人满意的结果(p > 0.05)。因此,研究结果表明,所提出的方法在食品安全和环境保护方面具有实际应用的巨大潜力。图形概要 。.
更新日期:2020-07-17
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