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The relationship between oxidative stress and acute ischemic stroke severity and functional outcome
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Pub Date : 2020-07-16 , DOI: 10.1186/s41983-020-00206-y
Wael M. Elsayed , El-Hady A. Abdel-Gawad , Dalia I. A. Mesallam , Tamer S. El-Serafy

Background Cerebral ischemia initiates an oxidative stress response in the brain which is a composite process that involves many oxidative stress biomarkers. High levels of malondialdehyde (MDA) in patients with acute ischemic stroke had been found. The evaluation of oxidative stress in the acute stage may contribute to improve the post ischemic stroke outcome. Objective The aim of the current study to assess MDA level, as an oxidative stress biomarker, in acute ischemic stroke on admission and its relation with stroke severity on admission and also, its relation with three months short-term outcome. Methods Forty-two patients (20 males and 22 females) with acute ischemic stroke were prospectively enrolled in follow-up cohort study. Serum MDA was measured within 24 h after admission. We studied the relationship between MDA and stroke severity and functional outcome after 3 months assessed by National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) respectively. Results Serum MDA levels correlated significantly with clinical short-term stroke outcome after 3 months ( p < 0.001). Conclusion(s) These data provide evidence that the MDA (an oxidative stress biomarker) may be used as predictor for functional outcome in acute ischemic stroke.

中文翻译:

氧化应激与急性缺血性卒中严重程度和功能结局的关系

背景脑缺血在大脑中引发氧化应激反应,这是一个涉及许多氧化应激生物标志物的复合过程。已发现急性缺血性中风患者的丙二醛 (MDA) 水平较高。急性期氧化应激的评估可能有助于改善缺血性卒中后的结局。目的 本研究的目的是评估 MDA 水平,作为氧化应激生物标志物,在入院时急性缺血性卒中及其与入院时卒中严重程度的关系,以及与 3 个月短期结果的关系。方法前瞻性纳入42例急性缺血性脑卒中患者(男20例,女22例)进行随访队列研究。入院后24小时内测量血清MDA。我们分别通过美国国立卫生研究院卒中量表 (NIHSS) 和改良 Rankin 量表 (mRS) 评估了 3 个月后 MDA 与卒中严重程度和功能结果之间的关系。结果 血清 MDA 水平与 3 个月后的临床短期卒中结果显着相关 (p < 0.001)。结论 这些数据提供证据表明 MDA(一种氧化应激生物标志物)可用作急性缺血性卒中功能结果的预测指标。
更新日期:2020-07-16
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