Primary immunodeficiences (PIDs) are a group of chronic, serious disorders in which the immune response is insufficient. In consequence, it leads to an increased susceptibility to infections. Up to date, there are about 350 different disorders classified in that group. There are also patients suffering from recurrent respiratory tract infections (RRTI), however that group doesn’t present any abnormalities in terms of conducted immunological tests. Many factors, including medical, can have an impact on physical development of a child. Data such as birth weight and length, also weight, height, BMI during admission to the hospital were collected from 195 patients’ medical histories from their hospitalization at Clinical Immunology and Paediatrics Ward of J. Gromkowski Hospital in Wrocław. Investigated groups included patients with PIDs, RRTI and a control group of healthy children. Our purpose was to evaluate the physical growth of children with PID and children with RRTI by assessment of their height and weight. All of parameters were evaluated using centile charts, suitable best for the Polish population. The lowest mean birth weight and height was found among the PIDs patients group. Children with PIDs during hospitalization had statistically relevant lower mean weight than the control group and almost 18% of them had their height situated below 3rd percentile. The statistically relevant differences have been found between them and RRTI group in terms of weight, height and nutritional status. The statistically significant difference was detected between the nutritional status of PID and control group. There is a higher percentage of PID patients with physical growth abnormalities in comparison to healthy children. Our findings indicate a need for further investigation of immune system irregularities and their influence on physical growth of children.

中文翻译：

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评估原发性免疫缺陷病患者和反复呼吸道感染儿童组的体重和身高。

原发性免疫缺陷 (PID) 是一组免疫反应不足的慢性严重疾病。结果，它导致对感染的易感性增加。迄今为止，大约有 350 种不同的疾病被归入该组。也有患有反复呼吸道感染 (RRTI) 的患者，但该组在进行的免疫学测试方面没有出现任何异常。许多因素，包括医疗因素，都会影响儿童的身体发育。从他们在弗罗茨瓦夫 J. Gromkowski 医院的临床免疫学和儿科病房住院的 195 名患者的病史中收集了出生体重和身长，以及入院期间的体重、身高、BMI 等数据。研究组包括 PID 患者、RRTI 和健康儿童对照组。我们的目的是通过评估 PID 儿童和 RRTI 儿童的身高和体重来评估他们的身体发育情况。所有参数都使用百分位图进行评估，最适合波兰人口。在 PID 患者组中发现了最低的平均出生体重和身高。住院期间患有 PID 的儿童的平均体重在统计学上低于对照组，其中近 18% 的儿童身高低于第 3 个百分位数。已发现他们与 RRTI 组在体重、身高和营养状况方面存在统计学相关差异。PID组与对照组的营养状况差异有统计学意义。与健康儿童相比，PID 患者身体发育异常的比例更高。我们的研究结果表明需要进一步调查免疫系统异常及其对儿童身体发育的影响。