Background and aims: We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension. Methods and results: Forty women with arterial hypertension, 20–50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing Lactobacillus para casei LPC-37, Lactobacillus rhamnosus HN001, Lactobacillus acidophilus NCFM, and Bifidobacterium lactis HN019 (10⁹ CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day⁻¹, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups (p > 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL⁻¹, p < 0.05) and cholesterol levels (change −23.6 mg dL⁻¹, p < 0.05), and increased the HDL-cholesterol (change 6.5 mg dL⁻¹, p < 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio (p < 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation. Conclusion: Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.

中文翻译：

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益生菌治疗对高血压女性心脏代谢参数和自主神经调节的影响：一项随机，三盲，安慰剂对照试验。

背景与目的：我们评估了8周的益生菌治疗对医学诊断患有高血压的女性心脏代谢变量和自主神经功能的影响。方法和结果：在这项随机，三盲，安慰剂对照的临床试验中，将40位20至50岁的动脉高血压妇女分为两组。益生菌组的患者每天接受一袋含有副干酪乳杆菌LPC-37，鼠李糖乳杆菌HN001，嗜酸乳杆菌NCFM和乳酸双歧杆菌HN019（每株10 ⁹ CFU）的香囊，持续8周。安慰剂组的患者接受同样的小袋聚右旋糖（每天1克）^-1，持续8周）。在基线和干预8周后评估人体测量学，血压，心电图，生化测量，粪便微生物群组成和葡萄糖氢呼气试验。两组之间的人体测量学变量（体重，BMI和腰围）相似（ p > 0.05）。补充益生菌可显着降低空腹血糖（变化-10.3 mg dL ^-1， p <0.05）和胆固醇水平（变化-23.6 mg dL ^-1， p <0.05），并增加HDL-胆固醇（变化6.5 mg dL ^-1， p<0.05）与基准条件相比。尽管没有统计学意义，但补充益生菌可使高血压妇女的收缩压降低约5 mmHg，舒张压降低约2 mmHg。最后，在心率变异性的频域中，益生菌给药可降低低频（LF）振荡和LF /高频（HF）比率（p <0.05），表明自主神经调节能力得到改善。结论：为期8周的益生菌疗法可降低高血压妇女的空腹血糖水平，并改善其脂质状况和自主神经调节作用。