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Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
Genes & Development ( IF 10.5 ) Pub Date : 2020-08-01 , DOI: 10.1101/gad.339119.120 Lin Lin 1 , George A Lemieux 1 , Osatohanmwen Jessica Enogieru 2 , Kathleen M Giacomini 2 , Kaveh Ashrafi 1
Genes & Development ( IF 10.5 ) Pub Date : 2020-08-01 , DOI: 10.1101/gad.339119.120 Lin Lin 1 , George A Lemieux 1 , Osatohanmwen Jessica Enogieru 2 , Kathleen M Giacomini 2 , Kaveh Ashrafi 1
Affiliation
Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral resources. The mechanisms that import Kyn into the nervous system are poorly understood. Here, we provide genetic, anatomical, biochemical, and behavioral evidence showing that in C. elegans an ortholog of the human LAT1 transporter, AAT-1, imports Kyn into sites of KynA production.
中文翻译:
秀丽隐杆线虫中神经尿酸的生成需要AAT-1转运蛋白。
尿酸(KynA)水平将周围的代谢状态与包括学习和记忆在内的神经功能联系起来。由于神经KynA水平会抑制学习能力,因此已提出减少KynA作为认知缺陷(如神经退行性疾病)的治疗策略。虽然KynA是在神经系统内局部产生的,但其前体犬尿氨酸(Kynnurenine(Kyn))主要来自周围资源。将Kyn导入神经系统的机制了解甚少。在这里,我们提供的遗传,解剖,生化和行为证据表明,在秀丽隐杆线虫中,人类LAT1转运蛋白AAT-1的直系同源物将Kyn导入KynA生产场所。
更新日期:2020-08-03
中文翻译:
秀丽隐杆线虫中神经尿酸的生成需要AAT-1转运蛋白。
尿酸(KynA)水平将周围的代谢状态与包括学习和记忆在内的神经功能联系起来。由于神经KynA水平会抑制学习能力,因此已提出减少KynA作为认知缺陷(如神经退行性疾病)的治疗策略。虽然KynA是在神经系统内局部产生的,但其前体犬尿氨酸(Kynnurenine(Kyn))主要来自周围资源。将Kyn导入神经系统的机制了解甚少。在这里,我们提供的遗传,解剖,生化和行为证据表明,在秀丽隐杆线虫中,人类LAT1转运蛋白AAT-1的直系同源物将Kyn导入KynA生产场所。