Background. This meta-analysis was to evaluate the efficacy of autologous stem cell administration for the treatment of diabetic foot. Methods. The electronic databases included PubMed, EMBASE, BIOSIS, Cochrane central, and Google Scholar internet, last updated on May 30, 2019. Evaluated outcomes included the rate of wound healing and amputation. Dichotomous outcomes were described as risk ratios (RR) with 95% confidence intervals (CIs). Statistical analysis was performed with RevMan 5.0 software and STATA 10.0 software. Results. Eight randomized controlled trial (RCT) studies were included in this study. The meta-analysis showed a lower amputation (RR 0.25, 95% CI 0.11 to 0.54, ) and a higher wound healing rate (RR 2.05, 95% CI 1.67 to 2.51, ) in the cell therapy group compared with control. Conclusion. This meta-analysis supports the effective role of stem cell therapy in promoting wound healing and decreasing rate of amputation in diabetic foot. In the future, more high quality and well-designed studies are need.

中文翻译：

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自体干细胞治疗糖尿病足：随机研究的荟萃分析。

背景。该荟萃分析旨在评估自体干细胞给药治疗糖尿病足的疗效。方法。电子数据库包括 PubMed、EMBASE、BIOSIS、Cochrane Central 和 Google Scholar 互联网，最后更新于 2019 年 5 月 30 日。评估结果包括伤口愈合率和截肢率。二分类结果被描述为具有 95% 置信区间 (CI) 的风险比 (RR)。使用 RevMan 5.0 软件和 STATA 10.0 软件进行统计分析。结果。本研究纳入了八项随机对照试验（RCT）研究。荟萃分析显示截肢率较低（RR 0.25，95% CI 0.11 至 0.54，)和更高的伤口愈合率 (RR 2.05, 95% CI 1.67 to 2.51,)细胞治疗组与对照组相比。结论。这项荟萃分析支持干细胞疗法在促进伤口愈合和降低糖尿病足截肢率方面的有效作用。未来，需要更多高质量和精心设计的研究。