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Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae)
Zeitschrift für Naturforschung C ( IF 2 ) Pub Date : 2021-01-27 , DOI: 10.1515/znc-2020-0136
Phu Hoang Dang 1, 2 , Tho Huu Le 1, 2 , Truong Nhat Van Do 1, 2 , Hai Xuan Nguyen 1, 2 , Mai Thanh Thi Nguyen 1, 2, 3 , Nhan Trung Nguyen 1, 2, 3
Affiliation  

Abstract From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), decumbic anhydride (1) and four known compounds 2–5 were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of 13C NMR chemical shifts was carried out to clarify the structure of 1. The absolute configuration of 1 was assigned based on the Cotton effects in its ECD spectrum. Compound 1 showed potent tyrosinase inhibitory activity with an IC50 value of 52.2 μM.

中文翻译:

来自 Swintonia floribunda (Anacardiaceae) 茎皮的脱酸酐

摘要 从漆树科(漆树科)茎皮的可溶于 EtOAc 的部分中,分离出二酸酐 (1) 和四种已知化合物 2-5。基于光谱数据解释阐明了它们的化学结构。进行 13C NMR 化学位移的 GIAO-DFT 计算以阐明 1 的结构。 1 的绝对构型是基于其 ECD 光谱中的棉花效应指定的。化合物 1 显示出有效的酪氨酸酶抑制活性,IC50 值为 52.2 μM。
更新日期:2021-01-27
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