Airway remodeling in asthma is characterized by the presence of increased airway smooth muscle (ASM), increased mucus producing cells (submucosal mucous glands and epithelial goblet cells), and subepithelial fibrosis (deposition of collagen and extracellular matrix proteins) which all contribute to increased airway wall thickness.

中文翻译：

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染色体 17q21 SNP rs8076131 风险等位基因与致死性哮喘气道平滑肌肥大相关

哮喘气道重塑的特征在于气道平滑肌 (ASM) 增加、粘液产生细胞（粘膜下粘液腺和上皮杯状细胞）和上皮下纤维化（胶原蛋白和细胞外基质蛋白的沉积），这些都有助于增加气道室壁厚度。