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Griseofulvin dissolved in binary aqueous co-solvent mixtures of N,N-dimethylformamide, methanol, ethanol, acetonitrile and N-methylpyrrolidone: Solubility determination and thermodynamic studies
The Journal of Chemical Thermodynamics ( IF 2.6 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.jct.2020.106250
Xi Zhao , Ali Farajtabar , Gui Han , Hongkun Zhao

Abstract The equilibrium solubility of griseofulvin in five co-solvent mixtures of N,N-dimethylformamide (DMF) + water (2), methanol (1) + water (2) , ethanol (1) + water (2), acetonitrile (1) + water (2) and N-methylpyrrolidone (NMP) (1) + water (2) were acquired through experiment at temperatures covering from 278.15 K to 323.15 K by the saturation shake-flask technique. The maximum solubility appeared in the neat co-solvents of DMF/methanol/ethanol/acetonitrile/NMP for each mixture. The mole fraction solubility of griseofulvin in the five mixtures was well correlated via van’t Hoff–Jouyban-Acree model and Jouyban-Acree model acquiring values of relative average deviations

中文翻译:

灰黄霉素溶解在 N,N-二甲基甲酰胺、甲醇、乙醇、乙腈和 N-甲基吡咯烷酮的二元水性共溶剂混合物中:溶解度测定和热力学研究

摘要 灰黄霉素在 N,N-二甲基甲酰胺 (DMF) + 水 (2)、甲醇 (1) + 水 (2)、乙醇 (1) + 水 (2)、乙腈 (1) 五种共溶剂混合物中的平衡溶解度) + 水 (2) 和 N-甲基吡咯烷酮 (NMP) (1) + 水 (2) 通过饱和摇瓶技术在 278.15 K 至 323.15 K 的温度下通过实验获得。对于每种混合物,最大溶解度出现在 DMF/甲醇/乙醇/乙腈/NMP 的纯共溶剂中。灰黄霉素在五种混合物中的摩尔分数溶解度通过 van't Hoff-Jouyban-Acree 模型和 Jouyban-Acree 模型获得了相对平均偏差值的良好相关性
更新日期:2020-12-01
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