Abstract Laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) has become a powerful technique for the in situ direct determination of isotope ratios in various solid materials. Unlike conventional solution analysis, LA-MC-ICP-MS offers analysis with high spatial resolution, high sample throughput, minimal sample preparation, and low contamination. Although the performance of LA-MC-ICP-MS has been improved greatly in the past decades, it has its inherent disadvantages such as complex isotopic fractionation/mass bias behavior, severe matrix effect, and isobaric interference, which limits its usage. This review focuses on the latest developments related to isotopic fractionation, matrix effect, and isobaric interference as well as their correction methods for LA-MC-ICP-MS. It is evident that the appropriate correction methods for LA-MC-ICP-MS are essential to obtain accurate and precise isotope ratios and ensure the success of further applications.

中文翻译：

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用激光烧蚀多集电极电感耦合等离子体质谱法测量同位素比值的同位素分馏和干​​扰校正方法的批判性审查

摘要 激光烧蚀多接收器电感耦合等离子体质谱（LA-MC-ICP-MS）已成为原位直接测定各种固体材料中同位素比的有力技术。与传统的溶液分析不同，LA-MC-ICP-MS 提供的分析具有高空间分辨率、高样品通量、最少的样品制备和低污染。尽管 LA-MC-ICP-MS 的性能在过去的几十年中得到了很大的提升，但它有其固有的缺点，例如复杂的同位素分馏/质量偏差行为、严重的基质效应和同量异位素干扰，限制了其使用。本综述重点介绍了与同位素分馏、基质效应和同量异位素干扰相关的最新进展，以及它们对 LA-MC-ICP-MS 的校正方法。